Drug interactions
Methotrexate + Tepotinib
Severity: Moderate
Methotrexate and Tepotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tepotinib inhibits P-glycoprotein and may raise exposure to methotrexate, which is also a P-gp substrate. Higher methotrexate levels can increase myelosuppression, mucositis, hepatotoxicity and renal toxicity.
What this interaction means in plain words
Methotrexate and Tepotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methotrexate belongs to Oncology; Tepotinib belongs to Oncology.
Why it happens
Tepotinib inhibits P-gp efflux transport, reducing methotrexate elimination and increasing its systemic exposure.
What to do
Monitor blood counts, renal and liver function, and methotrexate levels where high-dose therapy is used. Reduce the methotrexate dose if signs of toxicity appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methotrexate
- Acitretin + Methotrexate Contraindicated
- Adenovirus types 4 and 7 live + Methotrexate Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Contraindicated
- Ketorolac + Methotrexate Contraindicated
- Measles mumps and rubella vaccine live + Methotrexate Contraindicated
- Measles mumps and rubella vaccine + Methotrexate Contraindicated
Other interactions of Tepotinib
- Colchicine + Tepotinib Major
- Digoxin + Tepotinib Major
- Tepotinib + Vincristine Major
- Amiodarone + Tepotinib Moderate
- Apixaban + Tepotinib Moderate
- Atorvastatin + Tepotinib Moderate
Frequently asked questions
Can I take Methotrexate with Tepotinib?
MediHelp rates the interaction as moderate. Methotrexate and Tepotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tepotinib inhibits P-glycoprotein and may raise exposure to methotrexate, which is also a P-gp substrate. Higher methotrexate levels can increase myelosuppression, mucositis, hepatotoxicity and renal toxicity.
How serious is the interaction between Methotrexate and Tepotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts, renal and liver function, and methotrexate levels where high-dose therapy is used. Reduce the methotrexate dose if signs of toxicity appear.
What other medicines interact with Methotrexate?
MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.
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