Drug interactions
Methoxsalen + Midazolam
Severity: Moderate
Methoxsalen and Midazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methoxsalen (8-methoxypsoralen) inhibits several CYP enzymes including CYP3A4 and may raise midazolam concentrations. This could deepen or prolong sedation.
What this interaction means in plain words
Methoxsalen and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methoxsalen belongs to Anti Fungals; Midazolam belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4-mediated midazolam metabolism by methoxsalen.
What to do
Start with a reduced midazolam dose and titrate slowly while monitoring sedation and respiration; extend observation during recovery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Methoxsalen
- Fezolinetant + Methoxsalen Contraindicated
- Demeclocycline + Methoxsalen Major
- Fedratinib + Methoxsalen Major
- Methoxsalen + Pirfenidone Major
- Methoxsalen + Tasimelteon Major
- Adapalene + Methoxsalen Moderate
Frequently asked questions
Can I take Methoxsalen with Midazolam?
MediHelp rates the interaction as moderate. Methoxsalen and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methoxsalen (8-methoxypsoralen) inhibits several CYP enzymes including CYP3A4 and may raise midazolam concentrations. This could deepen or prolong sedation.
How serious is the interaction between Methoxsalen and Midazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with a reduced midazolam dose and titrate slowly while monitoring sedation and respiration; extend observation during recovery.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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