Drug interactions
Methoxsalen + Perphenazine
Severity: Moderate
Methoxsalen and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both perphenazine and methoxsalen can cause photosensitivity. Using them together may increase the risk of exaggerated sunburn-like reactions and skin injury after UVA or sun exposure.
What this interaction means in plain words
Methoxsalen and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methoxsalen belongs to Anti Fungals; Perphenazine belongs to Central Nervous System.
Why it happens
Additive photosensitizing effects.
What to do
Counsel patients to strictly avoid sun exposure and use protective clothing and sunscreen. Monitor the skin response and adjust the UVA dose during phototherapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Other interactions of Methoxsalen
- Fezolinetant + Methoxsalen Contraindicated
- Demeclocycline + Methoxsalen Major
- Fedratinib + Methoxsalen Major
- Methoxsalen + Pirfenidone Major
- Methoxsalen + Tasimelteon Major
- Adapalene + Methoxsalen Moderate
Frequently asked questions
Can I take Methoxsalen with Perphenazine?
MediHelp rates the interaction as moderate. Methoxsalen and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both perphenazine and methoxsalen can cause photosensitivity. Using them together may increase the risk of exaggerated sunburn-like reactions and skin injury after UVA or sun exposure.
How serious is the interaction between Methoxsalen and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to strictly avoid sun exposure and use protective clothing and sunscreen. Monitor the skin response and adjust the UVA dose during phototherapy.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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