Drug interactions
Methoxsalen + Pomalidomide
Severity: Moderate
Methoxsalen and Pomalidomide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pomalidomide is cleared substantially via CYP1A2, and methoxsalen is a potent CYP1A2 inhibitor. Raised pomalidomide exposure could worsen neutropenia, thrombocytopenia and other toxicities.
What this interaction means in plain words
Methoxsalen and Pomalidomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methoxsalen belongs to Anti Fungals; Pomalidomide belongs to Miscellaneous.
Why it happens
Methoxsalen inhibition of CYP1A2 decreases pomalidomide clearance.
What to do
Avoid the combination if possible; otherwise reduce the pomalidomide dose as the labeling advises for strong CYP1A2 inhibitors and monitor blood counts.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methoxsalen
- Fezolinetant + Methoxsalen Contraindicated
- Demeclocycline + Methoxsalen Major
- Fedratinib + Methoxsalen Major
- Methoxsalen + Pirfenidone Major
- Methoxsalen + Tasimelteon Major
- Adapalene + Methoxsalen Moderate
Other interactions of Pomalidomide
- Deferiprone + Pomalidomide Major
- Ethinyl estradiol-drospirenone + Pomalidomide Major
- Fluvoxamine + Pomalidomide Major
- Apalutamide + Pomalidomide Moderate
- Brivaracetam + Pomalidomide Moderate
- Carbamazepine + Pomalidomide Moderate
Frequently asked questions
Can I take Methoxsalen with Pomalidomide?
MediHelp rates the interaction as moderate. Methoxsalen and Pomalidomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pomalidomide is cleared substantially via CYP1A2, and methoxsalen is a potent CYP1A2 inhibitor. Raised pomalidomide exposure could worsen neutropenia, thrombocytopenia and other toxicities.
How serious is the interaction between Methoxsalen and Pomalidomide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible; otherwise reduce the pomalidomide dose as the labeling advises for strong CYP1A2 inhibitors and monitor blood counts.
What other medicines interact with Methoxsalen?
MediHelp also lists interactions of Methoxsalen with, for example, Fezolinetant, Demeclocycline, Fedratinib. The full list is on the Methoxsalen page.
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