Drug interactions
Methoxsalen + Tazemetostat
Severity: Moderate
Methoxsalen and Tazemetostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methoxsalen may inhibit CYP3A4 and raise tazemetostat exposure, potentially increasing its adverse effects. The clinical magnitude with methoxsalen is not well characterized.
What this interaction means in plain words
Methoxsalen and Tazemetostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methoxsalen belongs to Anti Fungals; Tazemetostat belongs to Miscellaneous.
Why it happens
Inhibition of CYP3A4-mediated tazemetostat metabolism.
What to do
Monitor for tazemetostat toxicity such as cytopenias and fatigue. Consider an alternative to methoxsalen if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methoxsalen
- Fezolinetant + Methoxsalen Contraindicated
- Demeclocycline + Methoxsalen Major
- Fedratinib + Methoxsalen Major
- Methoxsalen + Pirfenidone Major
- Methoxsalen + Tasimelteon Major
- Adapalene + Methoxsalen Moderate
Other interactions of Tazemetostat
Frequently asked questions
Can I take Methoxsalen with Tazemetostat?
MediHelp rates the interaction as moderate. Methoxsalen and Tazemetostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methoxsalen may inhibit CYP3A4 and raise tazemetostat exposure, potentially increasing its adverse effects. The clinical magnitude with methoxsalen is not well characterized.
How serious is the interaction between Methoxsalen and Tazemetostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tazemetostat toxicity such as cytopenias and fatigue. Consider an alternative to methoxsalen if feasible.
What other medicines interact with Methoxsalen?
MediHelp also lists interactions of Methoxsalen with, for example, Fezolinetant, Demeclocycline, Fedratinib. The full list is on the Methoxsalen page.
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