Drug interactions
Methscopolamine + Prochlorperazine
Severity: Moderate
Methscopolamine and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methscopolamine is an antimuscarinic, and prochlorperazine adds anticholinergic activity. Together they can cause dry mouth, constipation, urinary retention, blurred vision and tachycardia, especially in older adults.
What this interaction means in plain words
Methscopolamine and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic effects through pharmacodynamic synergism.
What to do
Monitor for anticholinergic adverse effects and avoid in patients with ileus, urinary retention or narrow-angle glaucoma. Lower the dose of one agent if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Frequently asked questions
Can I take Methscopolamine with Prochlorperazine?
MediHelp rates the interaction as moderate. Methscopolamine and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methscopolamine is an antimuscarinic, and prochlorperazine adds anticholinergic activity. Together they can cause dry mouth, constipation, urinary retention, blurred vision and tachycardia, especially in older adults.
How serious is the interaction between Methscopolamine and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects and avoid in patients with ileus, urinary retention or narrow-angle glaucoma. Lower the dose of one agent if symptoms occur.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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