Drug interactions
Methscopolamine + Umeclidinium
Severity: Moderate
Methscopolamine and Umeclidinium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methscopolamine is an oral quaternary antimuscarinic, and it adds to the anticholinergic effects of umeclidinium. This can raise the risk of dry mouth, constipation, urinary retention and tachycardia.
What this interaction means in plain words
Methscopolamine and Umeclidinium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive muscarinic receptor antagonism.
What to do
Avoid long-term combination when possible. Monitor for urinary retention, constipation and ocular symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Umeclidinium
- Tiotropium + Umeclidinium Major
- Aclidinium + Umeclidinium Moderate
- Atropine iv / + Umeclidinium Moderate
- Atropine + Umeclidinium Moderate
- Belladonna alkaloids + Umeclidinium Moderate
- Bethanechol + Umeclidinium Moderate
Frequently asked questions
Can I take Methscopolamine with Umeclidinium?
MediHelp rates the interaction as moderate. Methscopolamine and Umeclidinium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methscopolamine is an oral quaternary antimuscarinic, and it adds to the anticholinergic effects of umeclidinium. This can raise the risk of dry mouth, constipation, urinary retention and tachycardia.
How serious is the interaction between Methscopolamine and Umeclidinium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid long-term combination when possible. Monitor for urinary retention, constipation and ocular symptoms.
What other medicines interact with Umeclidinium?
MediHelp also lists interactions of Umeclidinium with, for example, Tiotropium, Aclidinium, Atropine iv /. The full list is on the Umeclidinium page.
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