Drug interactions
Methsuximide + Secobarbital
Severity: Minor
Methsuximide and Secobarbital: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methsuximide may alter barbiturate concentrations and anticonvulsant effect, and the combination may increase sedation. Interactions among antiepileptics are variable and not well characterized for this pair.
What this interaction means in plain words
Methsuximide and Secobarbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Methsuximide belongs to Central Nervous System; Secobarbital belongs to Central Nervous System.
Why it happens
Mechanism not firmly established; possible mutual effects on hepatic metabolism.
What to do
Monitor seizure control, sedation and serum levels of the antiepileptics when starting or stopping either drug.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Other interactions of Methsuximide
- Amisulpride + Methsuximide Moderate
- Amobarbital + Methsuximide Moderate
- Apalutamide + Methsuximide Moderate
- Asenapine + Methsuximide Moderate
- Brexpiprazole + Methsuximide Moderate
- Brivaracetam + Methsuximide Moderate
Frequently asked questions
Can I take Methsuximide with Secobarbital?
MediHelp rates the interaction as minor. Methsuximide and Secobarbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Methsuximide may alter barbiturate concentrations and anticonvulsant effect, and the combination may increase sedation. Interactions among antiepileptics are variable and not well characterized for this pair.
How serious is the interaction between Methsuximide and Secobarbital?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure control, sedation and serum levels of the antiepileptics when starting or stopping either drug.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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