Drug interactions
Methylenedioxymethamphetamine + Prochlorperazine
Severity: Moderate
Methylenedioxymethamphetamine and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MDMA is a serotonergic and sympathomimetic stimulant that can prolong QT and provoke arrhythmias and hyperthermia. Prochlorperazine adds dopamine blockade and some QT liability, and may worsen hyperthermia and cardiovascular instability. The combination can raise the risk of arrhythmia and neuroleptic-type reactions.
What this interaction means in plain words
Methylenedioxymethamphetamine and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic effects on cardiac repolarization and central monoaminergic and thermoregulatory pathways.
What to do
Avoid recreational MDMA use in patients taking prochlorperazine and obtain an ECG if recent use is suspected. Monitor temperature, heart rate and electrolytes in anyone presenting with both.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Frequently asked questions
Can I take Methylenedioxymethamphetamine with Prochlorperazine?
MediHelp rates the interaction as moderate. Methylenedioxymethamphetamine and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. MDMA is a serotonergic and sympathomimetic stimulant that can prolong QT and provoke arrhythmias and hyperthermia. Prochlorperazine adds dopamine blockade and some QT liability, and may worsen hyperthermia and cardiovascular instability. The combination can raise the risk of arrhythmia and neuroleptic-type reactions.
How serious is the interaction between Methylenedioxymethamphetamine and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid recreational MDMA use in patients taking prochlorperazine and obtain an ECG if recent use is suspected. Monitor temperature, heart rate and electrolytes in anyone presenting with both.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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