Drug interactions
Methylprednisolone + Miconazole
Severity: Moderate
Methylprednisolone and Miconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methylprednisolone is cleared by CYP3A4, and azole inhibitors can substantially raise its exposure. Miconazole absorbed from vaginal use produces a smaller effect. Increased exposure can lead to Cushingoid effects, hyperglycemia and immunosuppression.
What this interaction means in plain words
Methylprednisolone and Miconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methylprednisolone belongs to Endocrine; Miconazole belongs to Anti Fungals.
Why it happens
Miconazole inhibits CYP3A4, decreasing methylprednisolone clearance.
What to do
Monitor for corticosteroid excess such as hyperglycemia, fluid retention and infection. Consider lowering the methylprednisolone dose if prolonged or systemic miconazole is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Miconazole
Other interactions of Methylprednisolone
- Bcg vaccine live + Methylprednisolone Contraindicated
- Measles mumps and rubella vaccine live + Methylprednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Methylprednisolone Contraindicated
- Measles vaccine + Methylprednisolone Contraindicated
- Methylprednisolone + Mifepristone Contraindicated
- Methylprednisolone + Rubella vaccine Contraindicated
Frequently asked questions
Can I take Methylprednisolone with Miconazole?
MediHelp rates the interaction as moderate. Methylprednisolone and Miconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methylprednisolone is cleared by CYP3A4, and azole inhibitors can substantially raise its exposure. Miconazole absorbed from vaginal use produces a smaller effect. Increased exposure can lead to Cushingoid effects, hyperglycemia and immunosuppression.
How serious is the interaction between Methylprednisolone and Miconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for corticosteroid excess such as hyperglycemia, fluid retention and infection. Consider lowering the methylprednisolone dose if prolonged or systemic miconazole is needed.
What other medicines interact with Miconazole?
MediHelp also lists interactions of Miconazole with, for example, Cabazitaxel, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Miconazole page.
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