Drug interactions
Methylprednisolone + Naproxen
Severity: Moderate
Methylprednisolone and Naproxen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Taking a corticosteroid with naproxen raises the risk of peptic ulcer disease and gastrointestinal hemorrhage compared with either alone. The risk is greater in older adults and with prolonged use.
What this interaction means in plain words
Methylprednisolone and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methylprednisolone belongs to Endocrine; Naproxen belongs to Musculoskeletal.
Why it happens
Additive gastrointestinal mucosal injury: NSAID-related prostaglandin inhibition combined with corticosteroid impairment of mucosal healing.
What to do
Limit the dose and duration of both drugs, and add a proton pump inhibitor in patients at higher GI risk. Monitor for melena or anemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methylprednisolone
- Bcg vaccine live + Methylprednisolone Contraindicated
- Measles mumps and rubella vaccine live + Methylprednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Methylprednisolone Contraindicated
- Measles vaccine + Methylprednisolone Contraindicated
- Methylprednisolone + Mifepristone Contraindicated
- Methylprednisolone + Rubella vaccine Contraindicated
Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Frequently asked questions
Can I take Methylprednisolone with Naproxen?
MediHelp rates the interaction as moderate. Methylprednisolone and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Taking a corticosteroid with naproxen raises the risk of peptic ulcer disease and gastrointestinal hemorrhage compared with either alone. The risk is greater in older adults and with prolonged use.
How serious is the interaction between Methylprednisolone and Naproxen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit the dose and duration of both drugs, and add a proton pump inhibitor in patients at higher GI risk. Monitor for melena or anemia.
What other medicines interact with Methylprednisolone?
MediHelp also lists interactions of Methylprednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Methylprednisolone page.
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