Drug interactions
Methylprednisolone + Nelfinavir
Severity: Moderate
Methylprednisolone and Nelfinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nelfinavir inhibits CYP3A4 and can increase methylprednisolone exposure, raising the risk of systemic corticosteroid effects such as adrenal suppression and Cushingoid features with prolonged use.
What this interaction means in plain words
Methylprednisolone and Nelfinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methylprednisolone belongs to Endocrine; Nelfinavir belongs to Anti Virals.
Why it happens
Inhibition of CYP3A4 by nelfinavir reduces methylprednisolone clearance.
What to do
Use the lowest effective methylprednisolone dose and monitor for hyperglycemia, fluid retention and adrenal suppression; consider prednisolone for long-term therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methylprednisolone
- Bcg vaccine live + Methylprednisolone Contraindicated
- Measles mumps and rubella vaccine live + Methylprednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Methylprednisolone Contraindicated
- Measles vaccine + Methylprednisolone Contraindicated
- Methylprednisolone + Mifepristone Contraindicated
- Methylprednisolone + Rubella vaccine Contraindicated
Other interactions of Nelfinavir
- Alfuzosin + Nelfinavir Contraindicated
- Avanafil + Nelfinavir Contraindicated
- Dronedarone + Nelfinavir Contraindicated
- Eletriptan + Nelfinavir Contraindicated
- Ergotamine + Nelfinavir Contraindicated
- Flibanserin + Nelfinavir Contraindicated
Frequently asked questions
Can I take Methylprednisolone with Nelfinavir?
MediHelp rates the interaction as moderate. Methylprednisolone and Nelfinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nelfinavir inhibits CYP3A4 and can increase methylprednisolone exposure, raising the risk of systemic corticosteroid effects such as adrenal suppression and Cushingoid features with prolonged use.
How serious is the interaction between Methylprednisolone and Nelfinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective methylprednisolone dose and monitor for hyperglycemia, fluid retention and adrenal suppression; consider prednisolone for long-term therapy.
What other medicines interact with Methylprednisolone?
MediHelp also lists interactions of Methylprednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Methylprednisolone page.
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