Drug interactions
Methylprednisolone + Nifedipine
Severity: Minor
Methylprednisolone and Nifedipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nifedipine is a CYP3A4 substrate with weak interaction potential, and any change in methylprednisolone exposure is expected to be small. No meaningful clinical effect is established.
What this interaction means in plain words
Methylprednisolone and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Methylprednisolone belongs to Endocrine; Nifedipine belongs to Cardiovascular.
Why it happens
Possible minor competition for CYP3A4 and P-glycoprotein; the mechanism is not well established.
What to do
No routine adjustment is required. Monitor blood pressure and steroid adverse effects as clinically indicated.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Methylprednisolone
- Bcg vaccine live + Methylprednisolone Contraindicated
- Measles mumps and rubella vaccine live + Methylprednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Methylprednisolone Contraindicated
- Measles vaccine + Methylprednisolone Contraindicated
- Methylprednisolone + Mifepristone Contraindicated
- Methylprednisolone + Rubella vaccine Contraindicated
Other interactions of Nifedipine
Frequently asked questions
Can I take Methylprednisolone with Nifedipine?
MediHelp rates the interaction as minor. Methylprednisolone and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nifedipine is a CYP3A4 substrate with weak interaction potential, and any change in methylprednisolone exposure is expected to be small. No meaningful clinical effect is established.
How serious is the interaction between Methylprednisolone and Nifedipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is required. Monitor blood pressure and steroid adverse effects as clinically indicated.
What other medicines interact with Methylprednisolone?
MediHelp also lists interactions of Methylprednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Methylprednisolone page.
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