Drug interactions
Methylprednisolone + Nilotinib
Severity: Moderate
Methylprednisolone and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib inhibits CYP3A4 and P-glycoprotein and may raise methylprednisolone exposure, which could intensify corticosteroid adverse effects. Nilotinib itself prolongs the QT interval, and steroid-related electrolyte changes may add to that concern.
What this interaction means in plain words
Methylprednisolone and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methylprednisolone belongs to Endocrine; Nilotinib belongs to Oncology.
Why it happens
Inhibition of CYP3A4 metabolism and P-glycoprotein efflux by nilotinib raises methylprednisolone concentrations.
What to do
Monitor for signs of corticosteroid excess and reduce the methylprednisolone dose if they occur. Check potassium and magnesium and follow routine ECG monitoring for nilotinib.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Methylprednisolone and Nilotinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Methylprednisolone
- Bcg vaccine live + Methylprednisolone Contraindicated
- Measles mumps and rubella vaccine live + Methylprednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Methylprednisolone Contraindicated
- Measles vaccine + Methylprednisolone Contraindicated
- Methylprednisolone + Mifepristone Contraindicated
- Methylprednisolone + Rubella vaccine Contraindicated
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Methylprednisolone with Nilotinib?
MediHelp rates the interaction as moderate. Methylprednisolone and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilotinib inhibits CYP3A4 and P-glycoprotein and may raise methylprednisolone exposure, which could intensify corticosteroid adverse effects. Nilotinib itself prolongs the QT interval, and steroid-related electrolyte changes may add to that concern.
How serious is the interaction between Methylprednisolone and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of corticosteroid excess and reduce the methylprednisolone dose if they occur. Check potassium and magnesium and follow routine ECG monitoring for nilotinib.
What other medicines interact with Methylprednisolone?
MediHelp also lists interactions of Methylprednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Methylprednisolone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
