Drug interactions
Methylprednisolone + Somapacitan
Severity: Moderate
Methylprednisolone and Somapacitan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glucocorticoids can blunt the growth-promoting effects of growth hormone. Growth hormone may also alter cortisol metabolism, which can affect the adequacy of glucocorticoid replacement in hypoadrenal patients, though methylprednisolone is not a substrate for this activation step.
What this interaction means in plain words
Methylprednisolone and Somapacitan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methylprednisolone belongs to Endocrine; Somapacitan belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism of growth hormone by glucocorticoids, and growth hormone inhibition of 11-beta-HSD1 affecting cortisone activation.
What to do
Monitor growth velocity and adjust the somapacitan dose as needed, using the lowest effective glucocorticoid dose. In patients on cortisone or hydrocortisone replacement, reassess the dose after starting growth hormone.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methylprednisolone
- Bcg vaccine live + Methylprednisolone Contraindicated
- Measles mumps and rubella vaccine live + Methylprednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Methylprednisolone Contraindicated
- Measles vaccine + Methylprednisolone Contraindicated
- Methylprednisolone + Mifepristone Contraindicated
- Methylprednisolone + Rubella vaccine Contraindicated
Other interactions of Somapacitan
- Alogliptin-metformin + Somapacitan Moderate
- Alogliptin-pioglitazone + Somapacitan Moderate
- Alogliptin + Somapacitan Moderate
- Bazedoxifene-conjugated estrogens + Somapacitan Moderate
- Canagliflozin-metformin + Somapacitan Moderate
- Chlorpropamide + Somapacitan Moderate
Frequently asked questions
Can I take Methylprednisolone with Somapacitan?
MediHelp rates the interaction as moderate. Methylprednisolone and Somapacitan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glucocorticoids can blunt the growth-promoting effects of growth hormone. Growth hormone may also alter cortisol metabolism, which can affect the adequacy of glucocorticoid replacement in hypoadrenal patients, though methylprednisolone is not a substrate for this activation step.
How serious is the interaction between Methylprednisolone and Somapacitan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor growth velocity and adjust the somapacitan dose as needed, using the lowest effective glucocorticoid dose. In patients on cortisone or hydrocortisone replacement, reassess the dose after starting growth hormone.
What other medicines interact with Methylprednisolone?
MediHelp also lists interactions of Methylprednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Methylprednisolone page.
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