Drug interactions
Methylprednisolone + Somatrogon
Severity: Moderate
Methylprednisolone and Somatrogon: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
High-dose glucocorticoid exposure can blunt the growth response to somatrogon in children. Growth may be suboptimal unless glucocorticoid dosing is minimized.
What this interaction means in plain words
Methylprednisolone and Somatrogon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methylprednisolone belongs to Endocrine; Somatrogon belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism of growth hormone effects by glucocorticoids.
What to do
Keep the glucocorticoid dose as low as clinically possible and monitor growth velocity, adjusting the somatrogon dose as appropriate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methylprednisolone
- Bcg vaccine live + Methylprednisolone Contraindicated
- Measles mumps and rubella vaccine live + Methylprednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Methylprednisolone Contraindicated
- Measles vaccine + Methylprednisolone Contraindicated
- Methylprednisolone + Mifepristone Contraindicated
- Methylprednisolone + Rubella vaccine Contraindicated
Other interactions of Somatrogon
- Alogliptin-metformin + Somatrogon Moderate
- Alogliptin-pioglitazone + Somatrogon Moderate
- Alogliptin + Somatrogon Moderate
- Canagliflozin-metformin + Somatrogon Moderate
- Chlorpropamide + Somatrogon Moderate
- Cyclosporin + Somatrogon Moderate
Frequently asked questions
Can I take Methylprednisolone with Somatrogon?
MediHelp rates the interaction as moderate. Methylprednisolone and Somatrogon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. High-dose glucocorticoid exposure can blunt the growth response to somatrogon in children. Growth may be suboptimal unless glucocorticoid dosing is minimized.
How serious is the interaction between Methylprednisolone and Somatrogon?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep the glucocorticoid dose as low as clinically possible and monitor growth velocity, adjusting the somatrogon dose as appropriate.
What other medicines interact with Methylprednisolone?
MediHelp also lists interactions of Methylprednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Methylprednisolone page.
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