Drug interactions
Metoclopramide + Opium tincture
Severity: Moderate
Metoclopramide and Opium tincture: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opium tincture slows gastrointestinal transit and counteracts the prokinetic action of metoclopramide. Both agents may cause sedation, so central depression can also be additive.
What this interaction means in plain words
Metoclopramide and Opium tincture can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opioid-mediated reduction in gut motility opposes metoclopramide, with additive CNS depression.
What to do
Monitor for loss of metoclopramide effect and for excessive sedation. Consider an alternative to one of the agents if the therapeutic goals conflict.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Frequently asked questions
Can I take Metoclopramide with Opium tincture?
MediHelp rates the interaction as moderate. Metoclopramide and Opium tincture can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opium tincture slows gastrointestinal transit and counteracts the prokinetic action of metoclopramide. Both agents may cause sedation, so central depression can also be additive.
How serious is the interaction between Metoclopramide and Opium tincture?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of metoclopramide effect and for excessive sedation. Consider an alternative to one of the agents if the therapeutic goals conflict.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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