Drug interactions
Metoclopramide + Orphenadrine
Severity: Moderate
Metoclopramide and Orphenadrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Orphenadrine is an anticholinergic that reduces gastrointestinal motility, opposing metoclopramide's prokinetic action. Both drugs may also cause drowsiness and dizziness.
What this interaction means in plain words
Metoclopramide and Orphenadrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism between anticholinergic and cholinergic prokinetic effects, plus additive CNS depression.
What to do
Monitor for reduced efficacy of metoclopramide and for sedation. Consider an alternative muscle relaxant or prokinetic strategy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Frequently asked questions
Can I take Metoclopramide with Orphenadrine?
MediHelp rates the interaction as moderate. Metoclopramide and Orphenadrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Orphenadrine is an anticholinergic that reduces gastrointestinal motility, opposing metoclopramide's prokinetic action. Both drugs may also cause drowsiness and dizziness.
How serious is the interaction between Metoclopramide and Orphenadrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced efficacy of metoclopramide and for sedation. Consider an alternative muscle relaxant or prokinetic strategy.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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