Drug interactions
Metoclopramide + Oxybutynin transdermal
Severity: Moderate
Metoclopramide and Oxybutynin transdermal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxybutynin is an antimuscarinic that reduces gastrointestinal motility, which opposes the prokinetic action of metoclopramide. The therapeutic benefit of metoclopramide for nausea, gastroparesis or reflux may be reduced.
What this interaction means in plain words
Metoclopramide and Oxybutynin transdermal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism between antimuscarinic inhibition of GI motility and cholinergic prokinetic effect of metoclopramide.
What to do
Monitor for loss of prokinetic efficacy and consider an alternative to the antimuscarinic if symptoms persist. Reassess the need for both drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Frequently asked questions
Can I take Metoclopramide with Oxybutynin transdermal?
MediHelp rates the interaction as moderate. Metoclopramide and Oxybutynin transdermal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxybutynin is an antimuscarinic that reduces gastrointestinal motility, which opposes the prokinetic action of metoclopramide. The therapeutic benefit of metoclopramide for nausea, gastroparesis or reflux may be reduced.
How serious is the interaction between Metoclopramide and Oxybutynin transdermal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of prokinetic efficacy and consider an alternative to the antimuscarinic if symptoms persist. Reassess the need for both drugs.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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