Drug interactions
Metoclopramide + Pentobarbital
Severity: Moderate
Metoclopramide and Pentobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents depress the central nervous system, so sedation and respiratory depression may be greater when they are combined. Metoclopramide may also lower the dose of sedative needed.
What this interaction means in plain words
Metoclopramide and Pentobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects.
What to do
Titrate the barbiturate carefully and monitor level of consciousness and respiration. Counsel about drowsiness if used outside a monitored setting.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Frequently asked questions
Can I take Metoclopramide with Pentobarbital?
MediHelp rates the interaction as moderate. Metoclopramide and Pentobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents depress the central nervous system, so sedation and respiratory depression may be greater when they are combined. Metoclopramide may also lower the dose of sedative needed.
How serious is the interaction between Metoclopramide and Pentobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate the barbiturate carefully and monitor level of consciousness and respiration. Counsel about drowsiness if used outside a monitored setting.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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