Drug interactions
Metoclopramide + Propantheline
Severity: Moderate
Metoclopramide and Propantheline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propantheline is an anticholinergic that slows gastrointestinal motility and opposes the prokinetic effect of metoclopramide. Metoclopramide efficacy may be reduced.
What this interaction means in plain words
Metoclopramide and Propantheline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism: anticholinergic inhibition of GI motility versus metoclopramide prokinetic action.
What to do
Avoid combining when a prokinetic effect is desired; otherwise monitor for reduced symptom control and adjust therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Metoclopramide and Propantheline, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Metoclopramide
Frequently asked questions
Can I take Metoclopramide with Propantheline?
MediHelp rates the interaction as moderate. Metoclopramide and Propantheline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propantheline is an anticholinergic that slows gastrointestinal motility and opposes the prokinetic effect of metoclopramide. Metoclopramide efficacy may be reduced.
How serious is the interaction between Metoclopramide and Propantheline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining when a prokinetic effect is desired; otherwise monitor for reduced symptom control and adjust therapy.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
