Drug interactions
Metoclopramide + Protriptyline
Severity: Moderate
Metoclopramide and Protriptyline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Protriptyline is partly metabolized by CYP2D6 and has anticholinergic effects that oppose metoclopramide's prokinetic action. Combined use may add sedation and, because both can affect dopaminergic and serotonergic pathways, raise the risk of extrapyramidal or serotonergic effects.
What this interaction means in plain words
Metoclopramide and Protriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Anticholinergic antagonism of prokinetic effect, additive CNS effects, and possible CYP2D6 competition.
What to do
Monitor for reduced gut motility response, sedation, tremor and rigidity. Use the lowest effective doses and a short metoclopramide course.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Frequently asked questions
Can I take Metoclopramide with Protriptyline?
MediHelp rates the interaction as moderate. Metoclopramide and Protriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Protriptyline is partly metabolized by CYP2D6 and has anticholinergic effects that oppose metoclopramide's prokinetic action. Combined use may add sedation and, because both can affect dopaminergic and serotonergic pathways, raise the risk of extrapyramidal or serotonergic effects.
How serious is the interaction between Metoclopramide and Protriptyline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced gut motility response, sedation, tremor and rigidity. Use the lowest effective doses and a short metoclopramide course.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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