Drug interactions
Metoclopramide + Remifentanil
Severity: Moderate
Metoclopramide and Remifentanil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids antagonize the prokinetic effect of metoclopramide on gastric emptying and add to its central sedation. Combined use can lead to increased drowsiness and respiratory depression.
What this interaction means in plain words
Metoclopramide and Remifentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metoclopramide belongs to Gastrointestinal Tract; Remifentanil belongs to Musculoskeletal.
Why it happens
Opioid mu-receptor effects reduce gastrointestinal motility opposing metoclopramide, with additive CNS depression.
What to do
Monitor sedation and respiratory status, and titrate remifentanil carefully. Expect reduced prokinetic effect of metoclopramide.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Other interactions of Remifentanil
- Alvimopan + Remifentanil Contraindicated
- Isocarboxazid + Remifentanil Contraindicated
- Olanzapine / samidorphan + Remifentanil Contraindicated
- Phenelzine + Remifentanil Contraindicated
- Benzhydrocodone / acetaminophen + Remifentanil Major
- Brexanolone + Remifentanil Major
Frequently asked questions
Can I take Metoclopramide with Remifentanil?
MediHelp rates the interaction as moderate. Metoclopramide and Remifentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opioids antagonize the prokinetic effect of metoclopramide on gastric emptying and add to its central sedation. Combined use can lead to increased drowsiness and respiratory depression.
How serious is the interaction between Metoclopramide and Remifentanil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory status, and titrate remifentanil carefully. Expect reduced prokinetic effect of metoclopramide.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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