Drug interactions
Metoclopramide + Selegiline transdermal
Severity: Major
Metoclopramide and Selegiline transdermal: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide may release catecholamines and is cautioned in patients taking monoamine oxidase inhibitors, which could provoke hypertensive responses. It also blocks dopamine receptors and may antagonize the dopaminergic benefit of selegiline in Parkinson's disease, although transdermal selegiline is used mainly for depression.
What this interaction means in plain words
Metoclopramide and Selegiline transdermal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Possible catecholamine release in the presence of MAO inhibition, plus dopamine receptor antagonism.
What to do
Avoid the combination where possible and use another antiemetic. If used, monitor blood pressure and for neurological symptoms.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Metoclopramide
Frequently asked questions
Can I take Metoclopramide with Selegiline transdermal?
MediHelp rates the interaction as major. Metoclopramide and Selegiline transdermal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Metoclopramide may release catecholamines and is cautioned in patients taking monoamine oxidase inhibitors, which could provoke hypertensive responses. It also blocks dopamine receptors and may antagonize the dopaminergic benefit of selegiline in Parkinson's disease, although transdermal selegiline is used mainly for depression.
How serious is the interaction between Metoclopramide and Selegiline transdermal?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and use another antiemetic. If used, monitor blood pressure and for neurological symptoms.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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