Drug interactions
Metoclopramide + Sufentanil sl
Severity: Moderate
Metoclopramide and Sufentanil sl: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sublingual sufentanil is an opioid that delays gastric emptying and reduces motility, countering metoclopramide's prokinetic effect. Additive sedation and CNS depression can also occur.
What this interaction means in plain words
Metoclopramide and Sufentanil sl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opioid-mediated GI hypomotility antagonizes metoclopramide, with additive CNS depressant effects.
What to do
Monitor sedation level and respiratory rate, particularly after dose changes. Judge the effectiveness of metoclopramide and adjust the antiemetic plan if it is ineffective.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Frequently asked questions
Can I take Metoclopramide with Sufentanil sl?
MediHelp rates the interaction as moderate. Metoclopramide and Sufentanil sl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sublingual sufentanil is an opioid that delays gastric emptying and reduces motility, countering metoclopramide's prokinetic effect. Additive sedation and CNS depression can also occur.
How serious is the interaction between Metoclopramide and Sufentanil sl?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation level and respiratory rate, particularly after dose changes. Judge the effectiveness of metoclopramide and adjust the antiemetic plan if it is ineffective.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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