Drug interactions
Metoclopramide + Thalidomide
Severity: Moderate
Metoclopramide and Thalidomide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can cause sedation and drowsiness, so concurrent use may increase CNS depression. Thalidomide's sedative effect is prominent, particularly at night.
What this interaction means in plain words
Metoclopramide and Thalidomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metoclopramide belongs to Gastrointestinal Tract; Thalidomide belongs to Miscellaneous.
Why it happens
Additive CNS depressant effects.
What to do
Monitor for excessive sedation and advise caution with driving. Give thalidomide at bedtime and reduce other sedatives where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Other interactions of Thalidomide
Frequently asked questions
Can I take Metoclopramide with Thalidomide?
MediHelp rates the interaction as moderate. Metoclopramide and Thalidomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can cause sedation and drowsiness, so concurrent use may increase CNS depression. Thalidomide's sedative effect is prominent, particularly at night.
How serious is the interaction between Metoclopramide and Thalidomide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and advise caution with driving. Give thalidomide at bedtime and reduce other sedatives where possible.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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