Drug interactions
Metoclopramide + Tiagabine
Severity: Moderate
Metoclopramide and Tiagabine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide may lower the seizure threshold, which can oppose the anticonvulsant effect of tiagabine in patients with epilepsy. Additive drowsiness and dizziness can also occur.
What this interaction means in plain words
Metoclopramide and Tiagabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic opposition of antiepileptic effect plus additive CNS depression.
What to do
Monitor seizure control and sedation when metoclopramide is started. Consider an alternative antiemetic in patients with poorly controlled seizures.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Frequently asked questions
Can I take Metoclopramide with Tiagabine?
MediHelp rates the interaction as moderate. Metoclopramide and Tiagabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metoclopramide may lower the seizure threshold, which can oppose the anticonvulsant effect of tiagabine in patients with epilepsy. Additive drowsiness and dizziness can also occur.
How serious is the interaction between Metoclopramide and Tiagabine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure control and sedation when metoclopramide is started. Consider an alternative antiemetic in patients with poorly controlled seizures.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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