Drug interactions
Metoclopramide + Topiramate
Severity: Minor
Metoclopramide and Topiramate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Additive drowsiness, dizziness and cognitive slowing may occur with combined use. Metoclopramide may also modestly increase topiramate absorption.
What this interaction means in plain words
Metoclopramide and Topiramate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metoclopramide belongs to Gastrointestinal Tract; Topiramate belongs to Central Nervous System.
Why it happens
Additive CNS depression; possible faster absorption from accelerated gastric emptying.
What to do
Counsel patients about additive sedation and monitor for adverse CNS effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Metoclopramide and Topiramate, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Metoclopramide
Other interactions of Topiramate
Frequently asked questions
Can I take Metoclopramide with Topiramate?
MediHelp rates the interaction as minor. Metoclopramide and Topiramate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Additive drowsiness, dizziness and cognitive slowing may occur with combined use. Metoclopramide may also modestly increase topiramate absorption.
How serious is the interaction between Metoclopramide and Topiramate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about additive sedation and monitor for adverse CNS effects.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
