Drug interactions
Metoclopramide + Triazolam
Severity: Moderate
Metoclopramide and Triazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the CNS, and combined use can cause excess sedation, impaired coordination and memory impairment. Faster gastric emptying from metoclopramide may also quicken triazolam absorption.
What this interaction means in plain words
Metoclopramide and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression with possibly accelerated oral absorption of the benzodiazepine.
What to do
Monitor for oversedation and use the lowest effective triazolam dose, especially in older adults. Counsel against driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Frequently asked questions
Can I take Metoclopramide with Triazolam?
MediHelp rates the interaction as moderate. Metoclopramide and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the CNS, and combined use can cause excess sedation, impaired coordination and memory impairment. Faster gastric emptying from metoclopramide may also quicken triazolam absorption.
How serious is the interaction between Metoclopramide and Triazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and use the lowest effective triazolam dose, especially in older adults. Counsel against driving and alcohol.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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