Drug interactions
Metoclopramide + Triprolidine
Severity: Minor
Metoclopramide and Triprolidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triprolidine's sedating and anticholinergic effects can add to metoclopramide's drowsiness and oppose its prokinetic action. Clinical consequences are usually mild.
What this interaction means in plain words
Metoclopramide and Triprolidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metoclopramide belongs to Gastrointestinal Tract; Triprolidine belongs to Respiratory.
Why it happens
Additive CNS depression and anticholinergic antagonism of gastrointestinal motility.
What to do
Counsel on additive drowsiness and consider a non-sedating antihistamine if sedation is problematic.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metoclopramide
Other interactions of Triprolidine
Frequently asked questions
Can I take Metoclopramide with Triprolidine?
MediHelp rates the interaction as minor. Metoclopramide and Triprolidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Triprolidine's sedating and anticholinergic effects can add to metoclopramide's drowsiness and oppose its prokinetic action. Clinical consequences are usually mild.
How serious is the interaction between Metoclopramide and Triprolidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on additive drowsiness and consider a non-sedating antihistamine if sedation is problematic.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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