Drug interactions
Metoclopramide + Venlafaxine
Severity: Moderate
Metoclopramide and Venlafaxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Venlafaxine raises serotonin and norepinephrine activity, and combining it with metoclopramide may increase the risk of serotonin syndrome. Extrapyramidal reactions can also occur.
What this interaction means in plain words
Metoclopramide and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metoclopramide belongs to Gastrointestinal Tract; Venlafaxine belongs to Central Nervous System.
Why it happens
Additive serotonergic effects with dopamine D2 blockade; venlafaxine is a weak CYP2D6 inhibitor.
What to do
Limit metoclopramide dose and duration and monitor for serotonin toxicity and movement disorders. Discontinue metoclopramide if they emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Frequently asked questions
Can I take Metoclopramide with Venlafaxine?
MediHelp rates the interaction as moderate. Metoclopramide and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Venlafaxine raises serotonin and norepinephrine activity, and combining it with metoclopramide may increase the risk of serotonin syndrome. Extrapyramidal reactions can also occur.
How serious is the interaction between Metoclopramide and Venlafaxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit metoclopramide dose and duration and monitor for serotonin toxicity and movement disorders. Discontinue metoclopramide if they emerge.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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