Drug interactions
Metoclopramide + Zaleplon
Severity: Moderate
Metoclopramide and Zaleplon: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combined use can intensify sedation, dizziness and psychomotor impairment. Metoclopramide may also speed zaleplon absorption.
What this interaction means in plain words
Metoclopramide and Zaleplon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metoclopramide belongs to Gastrointestinal Tract; Zaleplon belongs to Central Nervous System.
Why it happens
Additive central nervous system depression.
What to do
Use the lowest effective doses, avoid driving after dosing, and monitor for excessive sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Other interactions of Zaleplon
- Calcium / magnesium / potassium / sodium oxybates + Zaleplon Contraindicated
- Sodium oxybate + Zaleplon Contraindicated
- Brexanolone + Zaleplon Major
- Buprenorphine long-acting + Zaleplon Major
- Buprenorphine subdermal implant + Zaleplon Major
- Buprenorphine transdermal + Zaleplon Major
Frequently asked questions
Can I take Metoclopramide with Zaleplon?
MediHelp rates the interaction as moderate. Metoclopramide and Zaleplon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combined use can intensify sedation, dizziness and psychomotor impairment. Metoclopramide may also speed zaleplon absorption.
How serious is the interaction between Metoclopramide and Zaleplon?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses, avoid driving after dosing, and monitor for excessive sedation.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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