Drug interactions
Metoclopramide + Zolpidem
Severity: Moderate
Metoclopramide and Zolpidem: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combined use can intensify sedation, dizziness and psychomotor impairment, and metoclopramide may hasten zolpidem absorption. Complex sleep behaviors and next-day impairment are a concern.
What this interaction means in plain words
Metoclopramide and Zolpidem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metoclopramide belongs to Gastrointestinal Tract; Zolpidem belongs to Central Nervous System.
Why it happens
Additive central nervous system depression, with possible faster absorption.
What to do
Use the lowest zolpidem dose and warn about next-day impairment; monitor for excessive sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Other interactions of Zolpidem
Frequently asked questions
Can I take Metoclopramide with Zolpidem?
MediHelp rates the interaction as moderate. Metoclopramide and Zolpidem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combined use can intensify sedation, dizziness and psychomotor impairment, and metoclopramide may hasten zolpidem absorption. Complex sleep behaviors and next-day impairment are a concern.
How serious is the interaction between Metoclopramide and Zolpidem?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest zolpidem dose and warn about next-day impairment; monitor for excessive sedation.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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