Drug interactions
Metoclopramide intranasal + Propofol
Severity: Minor
Metoclopramide intranasal and Propofol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide can cause drowsiness and has central dopamine-blocking effects, and may add to sedation from propofol. Metoclopramide may also reduce propofol dose requirements.
What this interaction means in plain words
Metoclopramide intranasal and Propofol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive CNS effects; metoclopramide central dopamine antagonism may contribute to sedation.
What to do
Titrate propofol to effect and monitor sedation depth; no routine avoidance needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Metoclopramide intranasal and Propofol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Propofol
Frequently asked questions
Can I take Metoclopramide intranasal with Propofol?
MediHelp rates the interaction as minor. Metoclopramide intranasal and Propofol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Metoclopramide can cause drowsiness and has central dopamine-blocking effects, and may add to sedation from propofol. Metoclopramide may also reduce propofol dose requirements.
How serious is the interaction between Metoclopramide intranasal and Propofol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate propofol to effect and monitor sedation depth; no routine avoidance needed.
What other medicines interact with Propofol?
MediHelp also lists interactions of Propofol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Propofol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
