Drug interactions
Metoclopramide intranasal + Vilazodone
Severity: Moderate
Metoclopramide intranasal and Vilazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide is associated with extrapyramidal effects and, rarely, neuroleptic malignant syndrome. Serotonergic antidepressants may add to these risks, and serotonin syndrome has been reported with the combination.
What this interaction means in plain words
Metoclopramide intranasal and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic and dopaminergic effects; the mechanism is not fully established.
What to do
Monitor for movement disorders, agitation, and signs of serotonin syndrome. Choose a different antiemetic if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Metoclopramide intranasal and Vilazodone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Frequently asked questions
Can I take Metoclopramide intranasal with Vilazodone?
MediHelp rates the interaction as moderate. Metoclopramide intranasal and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metoclopramide is associated with extrapyramidal effects and, rarely, neuroleptic malignant syndrome. Serotonergic antidepressants may add to these risks, and serotonin syndrome has been reported with the combination.
How serious is the interaction between Metoclopramide intranasal and Vilazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for movement disorders, agitation, and signs of serotonin syndrome. Choose a different antiemetic if symptoms develop.
What other medicines interact with Vilazodone?
MediHelp also lists interactions of Vilazodone with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Vilazodone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
