Drug interactions
Metolazone + Naproxen
Severity: Moderate
Metolazone and Naproxen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Naproxen can reduce the diuretic and antihypertensive effect of metolazone and, together with a diuretic, may raise the risk of acute kidney injury, especially with volume depletion. Effects on potassium are variable.
What this interaction means in plain words
Metolazone and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metolazone belongs to Cardiovascular; Naproxen belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandins causes sodium and water retention and reduced renal perfusion, opposing diuretic action.
What to do
Monitor blood pressure, weight or edema, renal function and electrolytes during concurrent use. Adjust the diuretic dose if response is lost, or choose an alternative analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Other interactions of Metolazone
Frequently asked questions
Can I take Metolazone with Naproxen?
MediHelp rates the interaction as moderate. Metolazone and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Naproxen can reduce the diuretic and antihypertensive effect of metolazone and, together with a diuretic, may raise the risk of acute kidney injury, especially with volume depletion. Effects on potassium are variable.
How serious is the interaction between Metolazone and Naproxen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, weight or edema, renal function and electrolytes during concurrent use. Adjust the diuretic dose if response is lost, or choose an alternative analgesic.
What other medicines interact with Naproxen?
MediHelp also lists interactions of Naproxen with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Naproxen page.
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