Drug interactions
Metolazone + Nateglinide
Severity: Moderate
Metolazone and Nateglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metolazone may raise blood glucose and weaken the effect of nateglinide. Glycemic control may worsen after the diuretic is started.
What this interaction means in plain words
Metolazone and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metolazone belongs to Cardiovascular; Nateglinide belongs to Endocrine.
Why it happens
Thiazide-like diuretics impair insulin secretion and sensitivity, opposing insulin secretagogues.
What to do
Monitor blood glucose when metolazone is started or changed. Adjust the nateglinide dose or regimen if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metolazone
Other interactions of Nateglinide
- Albiglutide + Nateglinide Moderate
- Alogliptin-metformin + Nateglinide Moderate
- Alogliptin-pioglitazone + Nateglinide Moderate
- Alogliptin + Nateglinide Moderate
- Alpelisib + Nateglinide Moderate
- Amiodarone + Nateglinide Moderate
Frequently asked questions
Can I take Metolazone with Nateglinide?
MediHelp rates the interaction as moderate. Metolazone and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metolazone may raise blood glucose and weaken the effect of nateglinide. Glycemic control may worsen after the diuretic is started.
How serious is the interaction between Metolazone and Nateglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when metolazone is started or changed. Adjust the nateglinide dose or regimen if control worsens.
What other medicines interact with Metolazone?
MediHelp also lists interactions of Metolazone with, for example, Amifostine, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide. The full list is on the Metolazone page.
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