Drug interactions
Metolazone + Prednisolone
Severity: Moderate
Metolazone and Prednisolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metolazone is a potent potassium-wasting diuretic and combined with prednisolone can cause marked hypokalemia. Hypomagnesemia may also occur, raising arrhythmia risk.
What this interaction means in plain words
Metolazone and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metolazone belongs to Cardiovascular; Prednisolone belongs to Endocrine.
Why it happens
Additive renal potassium wasting from thiazide-like diuretic and glucocorticoid mineralocorticoid effects.
What to do
Check serum potassium and magnesium regularly, particularly early in therapy, and supplement as required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Metolazone and Prednisolone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Prednisolone
- Bcg vaccine live + Prednisolone Contraindicated
- Measles mumps and rubella vaccine live + Prednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Prednisolone Contraindicated
- Measles vaccine + Prednisolone Contraindicated
- Mifepristone + Prednisolone Contraindicated
- Prednisolone + Radium-223 dichloride Contraindicated
Other interactions of Metolazone
Frequently asked questions
Can I take Metolazone with Prednisolone?
MediHelp rates the interaction as moderate. Metolazone and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metolazone is a potent potassium-wasting diuretic and combined with prednisolone can cause marked hypokalemia. Hypomagnesemia may also occur, raising arrhythmia risk.
How serious is the interaction between Metolazone and Prednisolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and magnesium regularly, particularly early in therapy, and supplement as required.
What other medicines interact with Prednisolone?
MediHelp also lists interactions of Prednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Prednisolone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
