Drug interactions
Metolazone + Propranolol
Severity: Minor
Metolazone and Propranolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metolazone and propranolol have additive blood pressure lowering effects. Thiazide-related hypokalemia and impaired glucose tolerance may matter in some patients, and propranolol may mask hypoglycemia symptoms in those on antidiabetic drugs.
What this interaction means in plain words
Metolazone and Propranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metolazone belongs to Cardiovascular; Propranolol belongs to Cardiovascular.
Why it happens
Additive antihypertensive effects plus diuretic-related metabolic changes.
What to do
Monitor blood pressure, heart rate and serum potassium, and check glucose in diabetic patients. Adjust doses as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Metolazone and Propranolol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Metolazone
Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
- Arformoterol + Propranolol Major
Frequently asked questions
Can I take Metolazone with Propranolol?
MediHelp rates the interaction as minor. Metolazone and Propranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Metolazone and propranolol have additive blood pressure lowering effects. Thiazide-related hypokalemia and impaired glucose tolerance may matter in some patients, and propranolol may mask hypoglycemia symptoms in those on antidiabetic drugs.
How serious is the interaction between Metolazone and Propranolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and serum potassium, and check glucose in diabetic patients. Adjust doses as needed.
What other medicines interact with Metolazone?
MediHelp also lists interactions of Metolazone with, for example, Amifostine, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide. The full list is on the Metolazone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
