Drug interactions
Metolazone + Timolol
Severity: Minor
Metolazone and Timolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metolazone and systemic timolol add to each other's blood pressure lowering effect. Diuretic-induced hypokalemia may add arrhythmia risk in susceptible patients. Ophthalmic timolol has limited systemic exposure but absorption can occur.
What this interaction means in plain words
Metolazone and Timolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metolazone belongs to Cardiovascular; Timolol belongs to Cardiovascular.
Why it happens
Additive antihypertensive effects with diuretic-related potassium loss.
What to do
Monitor blood pressure, heart rate and serum potassium when either drug is started or adjusted. Replace potassium if low.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metolazone
Other interactions of Timolol
- Acebutolol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
- Atenolol-chlorthalidone + Timolol Major
Frequently asked questions
Can I take Metolazone with Timolol?
MediHelp rates the interaction as minor. Metolazone and Timolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Metolazone and systemic timolol add to each other's blood pressure lowering effect. Diuretic-induced hypokalemia may add arrhythmia risk in susceptible patients. Ophthalmic timolol has limited systemic exposure but absorption can occur.
How serious is the interaction between Metolazone and Timolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and serum potassium when either drug is started or adjusted. Replace potassium if low.
What other medicines interact with Metolazone?
MediHelp also lists interactions of Metolazone with, for example, Amifostine, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide. The full list is on the Metolazone page.
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