Drug interactions
Metolazone + Tretinoin
Severity: Minor
Metolazone and Tretinoin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metolazone, a thiazide-type diuretic, can cause photosensitivity, and tretinoin increases skin sensitivity to ultraviolet light. Combined use may increase sunburn-like reactions, though the effect is usually mild.
What this interaction means in plain words
Metolazone and Tretinoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metolazone belongs to Cardiovascular; Tretinoin belongs to Dermatology.
Why it happens
Additive photosensitizing effects on the skin.
What to do
Counsel on sun avoidance, protective clothing and sunscreen. Adjust the tretinoin regimen if skin irritation occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metolazone
Other interactions of Tretinoin
- Doxycycline + Tretinoin Major
- Minocycline + Tretinoin Major
- Omadacycline + Tretinoin Major
- Palovarotene + Tretinoin Major
- Sarecycline + Tretinoin Major
- Tetracycline + Tretinoin Major
Frequently asked questions
Can I take Metolazone with Tretinoin?
MediHelp rates the interaction as minor. Metolazone and Tretinoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Metolazone, a thiazide-type diuretic, can cause photosensitivity, and tretinoin increases skin sensitivity to ultraviolet light. Combined use may increase sunburn-like reactions, though the effect is usually mild.
How serious is the interaction between Metolazone and Tretinoin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on sun avoidance, protective clothing and sunscreen. Adjust the tretinoin regimen if skin irritation occurs.
What other medicines interact with Metolazone?
MediHelp also lists interactions of Metolazone with, for example, Amifostine, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide. The full list is on the Metolazone page.
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