Drug interactions
Metolazone + Valsartan
Severity: Moderate
Metolazone and Valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metolazone adds to the blood pressure lowering of valsartan and can cause hypotension and volume depletion, with a risk of renal function change. Valsartan tends to offset thiazide-induced potassium loss.
What this interaction means in plain words
Metolazone and Valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metolazone belongs to Cardiovascular; Valsartan belongs to Cardiovascular.
Why it happens
Additive antihypertensive effect via diuresis and angiotensin receptor blockade, with opposing potassium effects.
What to do
Monitor blood pressure, potassium, sodium and creatinine after starting or changing doses. Reduce the diuretic dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metolazone
Other interactions of Valsartan
- Aliskiren + Valsartan Contraindicated
- Sparsentan + Valsartan Contraindicated
- Aldesleukin + Valsartan Major
- Amifostine + Valsartan Major
- Amiloride + Valsartan Major
- Amlodipine-benazepril + Valsartan Major
Frequently asked questions
Can I take Metolazone with Valsartan?
MediHelp rates the interaction as moderate. Metolazone and Valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metolazone adds to the blood pressure lowering of valsartan and can cause hypotension and volume depletion, with a risk of renal function change. Valsartan tends to offset thiazide-induced potassium loss.
How serious is the interaction between Metolazone and Valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, potassium, sodium and creatinine after starting or changing doses. Reduce the diuretic dose if symptomatic hypotension occurs.
What other medicines interact with Metolazone?
MediHelp also lists interactions of Metolazone with, for example, Amifostine, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide. The full list is on the Metolazone page.
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