Drug interactions
Metoprolol + Nicardipine
Severity: Minor
Metoprolol and Nicardipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine is a dihydropyridine vasodilator, and with a beta-blocker blood pressure falls further. Hypotension can occur, and beta-blockade may in rare cases worsen heart failure in susceptible patients.
What this interaction means in plain words
Metoprolol and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metoprolol belongs to Cardiovascular; Nicardipine belongs to Cardiovascular.
Why it happens
Additive blood pressure lowering from calcium channel blockade and beta-1 blockade; nicardipine also inhibits CYP2D6 and may raise metoprolol exposure.
What to do
Monitor blood pressure and heart rate when starting or titrating either drug. Adjust doses if symptomatic hypotension or bradycardia develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metoprolol
- Metoprolol + Thioridazine Contraindicated
- Amifostine + Metoprolol Major
- Amiodarone + Metoprolol Major
- Atenolol-chlorthalidone + Metoprolol Major
- Atenolol + Metoprolol Major
- Betaxolol + Metoprolol Major
Other interactions of Nicardipine
Frequently asked questions
Can I take Metoprolol with Nicardipine?
MediHelp rates the interaction as minor. Metoprolol and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nicardipine is a dihydropyridine vasodilator, and with a beta-blocker blood pressure falls further. Hypotension can occur, and beta-blockade may in rare cases worsen heart failure in susceptible patients.
How serious is the interaction between Metoprolol and Nicardipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or titrating either drug. Adjust doses if symptomatic hypotension or bradycardia develops.
What other medicines interact with Metoprolol?
MediHelp also lists interactions of Metoprolol with, for example, Thioridazine, Amifostine, Amiodarone. The full list is on the Metoprolol page.
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