Drug interactions
Metoprolol + Oxaprozin
Severity: Moderate
Metoprolol and Oxaprozin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxaprozin can reduce the blood pressure lowering effect of metoprolol, particularly with regular use over more than a week. Loss of control of hypertension may occur.
What this interaction means in plain words
Metoprolol and Oxaprozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metoprolol belongs to Cardiovascular; Oxaprozin belongs to Musculoskeletal.
Why it happens
NSAID inhibition of vasodilatory prostaglandin synthesis and sodium and water retention antagonizes the antihypertensive effect of beta-blockers.
What to do
Monitor blood pressure when oxaprozin is started, changed or stopped, and adjust the antihypertensive dose if needed. Consider a non-NSAID analgesic such as paracetamol if appropriate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Other interactions of Metoprolol
- Metoprolol + Thioridazine Contraindicated
- Amifostine + Metoprolol Major
- Amiodarone + Metoprolol Major
- Atenolol-chlorthalidone + Metoprolol Major
- Atenolol + Metoprolol Major
- Betaxolol + Metoprolol Major
Frequently asked questions
Can I take Metoprolol with Oxaprozin?
MediHelp rates the interaction as moderate. Metoprolol and Oxaprozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxaprozin can reduce the blood pressure lowering effect of metoprolol, particularly with regular use over more than a week. Loss of control of hypertension may occur.
How serious is the interaction between Metoprolol and Oxaprozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when oxaprozin is started, changed or stopped, and adjust the antihypertensive dose if needed. Consider a non-NSAID analgesic such as paracetamol if appropriate.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
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