Drug interactions
Metoprolol + Pilocarpine
Severity: Moderate
Metoprolol and Pilocarpine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pilocarpine is a muscarinic agonist that can slow heart rate and affect conduction, and systemic absorption may add to the effects of metoprolol. Conduction disturbances are possible in susceptible patients, particularly with oral pilocarpine.
What this interaction means in plain words
Metoprolol and Pilocarpine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metoprolol belongs to Cardiovascular; Pilocarpine belongs to Miscellaneous.
Why it happens
Additive cardiac effects from muscarinic stimulation and beta-1 blockade.
What to do
Monitor heart rate and ECG in patients with conduction disease or bradycardia taking oral pilocarpine with metoprolol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoprolol
- Metoprolol + Thioridazine Contraindicated
- Amifostine + Metoprolol Major
- Amiodarone + Metoprolol Major
- Atenolol-chlorthalidone + Metoprolol Major
- Atenolol + Metoprolol Major
- Betaxolol + Metoprolol Major
Other interactions of Pilocarpine
- Amitriptyline + Pilocarpine Moderate
- Atenolol-chlorthalidone + Pilocarpine Moderate
- Atenolol + Pilocarpine Moderate
- Atropine + Pilocarpine Moderate
- Betaxolol + Pilocarpine Moderate
- Bethanechol + Pilocarpine Moderate
Frequently asked questions
Can I take Metoprolol with Pilocarpine?
MediHelp rates the interaction as moderate. Metoprolol and Pilocarpine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pilocarpine is a muscarinic agonist that can slow heart rate and affect conduction, and systemic absorption may add to the effects of metoprolol. Conduction disturbances are possible in susceptible patients, particularly with oral pilocarpine.
How serious is the interaction between Metoprolol and Pilocarpine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and ECG in patients with conduction disease or bradycardia taking oral pilocarpine with metoprolol.
What other medicines interact with Metoprolol?
MediHelp also lists interactions of Metoprolol with, for example, Thioridazine, Amifostine, Amiodarone. The full list is on the Metoprolol page.
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