Drug interactions
Metoprolol + Secobarbital
Severity: Moderate
Metoprolol and Secobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates induce hepatic enzymes and can lower metoprolol levels, weakening beta-blockade. The effect is slow to appear and to resolve after stopping.
What this interaction means in plain words
Metoprolol and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metoprolol belongs to Cardiovascular; Secobarbital belongs to Central Nervous System.
Why it happens
Barbiturate-induced hepatic enzyme induction increasing metoprolol clearance.
What to do
Monitor heart rate and blood pressure, and increase the metoprolol dose if needed. Consider a renally cleared beta-blocker such as atenolol if the barbiturate is continued.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoprolol
- Metoprolol + Thioridazine Contraindicated
- Amifostine + Metoprolol Major
- Amiodarone + Metoprolol Major
- Atenolol-chlorthalidone + Metoprolol Major
- Atenolol + Metoprolol Major
- Betaxolol + Metoprolol Major
Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Frequently asked questions
Can I take Metoprolol with Secobarbital?
MediHelp rates the interaction as moderate. Metoprolol and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates induce hepatic enzymes and can lower metoprolol levels, weakening beta-blockade. The effect is slow to appear and to resolve after stopping.
How serious is the interaction between Metoprolol and Secobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure, and increase the metoprolol dose if needed. Consider a renally cleared beta-blocker such as atenolol if the barbiturate is continued.
What other medicines interact with Metoprolol?
MediHelp also lists interactions of Metoprolol with, for example, Thioridazine, Amifostine, Amiodarone. The full list is on the Metoprolol page.
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