Drug interactions
Metoprolol + Sulindac
Severity: Moderate
Metoprolol and Sulindac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prolonged NSAID use can weaken the blood pressure lowering effect of beta-blockers. Sulindac has a smaller effect on blood pressure than some other NSAIDs, but loss of control is still possible.
What this interaction means in plain words
Metoprolol and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metoprolol belongs to Cardiovascular; Sulindac belongs to Musculoskeletal.
Why it happens
NSAID inhibition of vasodilatory prostaglandins causes sodium and fluid retention and opposes the antihypertensive action of the beta-blocker.
What to do
Check blood pressure after starting or stopping sulindac and again during sustained use. Adjust the antihypertensive regimen if control is lost or consider a different analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Other interactions of Metoprolol
- Metoprolol + Thioridazine Contraindicated
- Amifostine + Metoprolol Major
- Amiodarone + Metoprolol Major
- Atenolol-chlorthalidone + Metoprolol Major
- Atenolol + Metoprolol Major
- Betaxolol + Metoprolol Major
Frequently asked questions
Can I take Metoprolol with Sulindac?
MediHelp rates the interaction as moderate. Metoprolol and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Prolonged NSAID use can weaken the blood pressure lowering effect of beta-blockers. Sulindac has a smaller effect on blood pressure than some other NSAIDs, but loss of control is still possible.
How serious is the interaction between Metoprolol and Sulindac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood pressure after starting or stopping sulindac and again during sustained use. Adjust the antihypertensive regimen if control is lost or consider a different analgesic.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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