Drug interactions
Metrizamide + Prochlorperazine
Severity: Major
Metrizamide and Prochlorperazine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intrathecal metrizamide lowers the seizure threshold, and phenothiazines can do the same. Concurrent use increases the risk of seizures after myelography.
What this interaction means in plain words
Metrizamide and Prochlorperazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive lowering of seizure threshold; the exact mechanism is not firmly established.
What to do
Stop the phenothiazine at least 24 hours before intrathecal contrast and avoid restarting for about 24 hours afterwards; use a non-phenothiazine antiemetic if needed.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Frequently asked questions
Can I take Metrizamide with Prochlorperazine?
MediHelp rates the interaction as major. Metrizamide and Prochlorperazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Intrathecal metrizamide lowers the seizure threshold, and phenothiazines can do the same. Concurrent use increases the risk of seizures after myelography.
How serious is the interaction between Metrizamide and Prochlorperazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Stop the phenothiazine at least 24 hours before intrathecal contrast and avoid restarting for about 24 hours afterwards; use a non-phenothiazine antiemetic if needed.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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