Drug interactions
Mexiletine + Tipranavir
Severity: Moderate
Mexiletine and Tipranavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir, given with ritonavir, has complex enzyme effects and may alter mexiletine concentrations, though CYP2D6 inhibition is not an established property of this combination. Ritonavir inhibits CYP2D6 and CYP3A4 and could raise mexiletine levels with a risk of neurological and cardiac toxicity.
What this interaction means in plain words
Mexiletine and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mexiletine belongs to Cardiovascular; Tipranavir belongs to Anti Virals.
Why it happens
Ritonavir-boosted tipranavir may inhibit CYP2D6 and CYP3A4-mediated mexiletine metabolism, though the effect is not well characterized.
What to do
Monitor ECG and for signs of mexiletine toxicity such as tremor, dizziness and GI upset. Lower the mexiletine dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mexiletine
- Fezolinetant + Mexiletine Contraindicated
- Mexiletine + Pimozide Contraindicated
- Alosetron + Mexiletine Major
- Amiodarone + Mexiletine Major
- Clozapine + Mexiletine Major
- Cobicistat + Mexiletine Major
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Mexiletine with Tipranavir?
MediHelp rates the interaction as moderate. Mexiletine and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tipranavir, given with ritonavir, has complex enzyme effects and may alter mexiletine concentrations, though CYP2D6 inhibition is not an established property of this combination. Ritonavir inhibits CYP2D6 and CYP3A4 and could raise mexiletine levels with a risk of neurological and cardiac toxicity.
How serious is the interaction between Mexiletine and Tipranavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and for signs of mexiletine toxicity such as tremor, dizziness and GI upset. Lower the mexiletine dose if adverse effects occur.
What other medicines interact with Mexiletine?
MediHelp also lists interactions of Mexiletine with, for example, Fezolinetant, Pimozide, Alosetron. The full list is on the Mexiletine page.
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