Drug interactions
Miconazole + Ranolazine
Severity: Moderate
Miconazole and Ranolazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Miconazole may increase ranolazine concentrations, which raises dose-related QT prolongation, dizziness and nausea. Systemic absorption from vaginal products is low, which limits relevance to local use.
What this interaction means in plain words
Miconazole and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Miconazole belongs to Anti Fungals; Ranolazine belongs to Cardiovascular.
Why it happens
Miconazole inhibits CYP3A4 metabolism of ranolazine.
What to do
Avoid systemic miconazole with ranolazine. With vaginal use, monitor for dizziness, nausea and QT effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Miconazole
Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Frequently asked questions
Can I take Miconazole with Ranolazine?
MediHelp rates the interaction as moderate. Miconazole and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Miconazole may increase ranolazine concentrations, which raises dose-related QT prolongation, dizziness and nausea. Systemic absorption from vaginal products is low, which limits relevance to local use.
How serious is the interaction between Miconazole and Ranolazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid systemic miconazole with ranolazine. With vaginal use, monitor for dizziness, nausea and QT effects.
What other medicines interact with Miconazole?
MediHelp also lists interactions of Miconazole with, for example, Cabazitaxel, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Miconazole page.
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